Research Article
lncRNA-KCNQ1OT1: A Potential Target in Exosomes Derived from Adipose-Derived Stem Cells for the Treatment of Osteoporosis
Figure 1
TNF-α increases miR-141-5p expression, suppresses the viability, and promotes the apoptosis of primary osteoblasts in a dose-dependent manner. (a) TNF-α dose-dependently increased miR-141-5p expression as detected by qRT-PCR. (b, c) TNF-α reduced cell viability and increased cell apoptosis in a dose-dependent manner as detected by CCK-8 assay and flow cytometry, respectively. (d) TNF-α increased the protein expression level of Bax and cleaved-Caspase-3 dose-dependently as detected by immunoblotting. , , and .
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