Research Article

lncRNA-KCNQ1OT1: A Potential Target in Exosomes Derived from Adipose-Derived Stem Cells for the Treatment of Osteoporosis

Figure 4

ADSCs-Exos attenuate the effect of TNF-α on primary osteoblasts. (a) ADSCs-Exos attenuated the upregulation of miR-141-5p induced by TNF-α dose-dependently. (b) ADSCs-Exos mitigated the inhibition of TNF-α on cell viability in a dose-dependent manner. (c) ADSCs-Exos dose-dependently decreased the promotion of TNF-α on cleaved caspase-3 and Bax expression. (d) Flow cytometry analysis showed that ADSCs-Exos dose-dependently reversed TNF-α-induced cell apoptosis. , , and .
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