|
Sources of exosomes | Cargos | Species/models | Outcome | Ref. |
|
hWJMSCs | miR-30 | SD rats/left kidney ischemia for 45 mins | Inhibit DRP1 Antiapoptosis | [103] |
miR-15, miR-16 | SD rats/left kidney ischemia for 60 mins | Inhibit CX3CL1 Anti-inflammation | [104] |
_ | Rats/left kidney ischemia for 45 mins NRK-52E cells/hypoxia for 6 h | Activate Nrf2/ARE pathway Antioxidation | [105] |
|
hucMSCs | HGF mRNA | SD rats/left kidney ischemia for 1 h | Activate ERK 1/2 pathway Antiapoptosis | [106] |
_ | SD rats: 6 mg/kg cisplatin NRK-52E cells/5 μM cisplatin for 6 h | Activate ERK 1/2 pathway Antiapoptosis | [107] |
_ | C57BL/6 mice/CLP surgery | Inhibit NF-κB pathway Anti-inflammation | [108] |
_ | SD rats/unilateral ureteral obstruction NRK-52E cells/TGF-β1 | Inhibit TLR4/NF-κB pathway Anti-inflammation | [109] |
CK1δ, β-TRCP | SD rats/unilateral ureteral obstruction | Inhibit YAP activity Antifibrosis | [110] |
miR-125b-5p | C57BL/6 mice/bilateral kidneys ischemia for 30 mins HK-2 cells/hypoxia for 12 h | Inhibit p53 Antiapoptosis | [111] |
|
hADMSCs | _ | C57BL/6 mice/left kidney ischemia for 30 mins | Upregulate Sox9 Antifibrosis | [112] |
_ | C57BL/6 mice/CLP surgery | Activate SIRT1 Anti-inflammation, Antiapoptosis | [113] |
|
hUSCs | miR-146a-5p | SD rats/left kidney ischemia for 45 mins HK-2 cells/hypoxic medium 48 h | Downregulate IRAK1 Inhibit NF-κB pathway Anti-inflammation | [114] |
miR-216a-5p | SD rats/left kidney ischemia for 45 mins HK-2 cells/hypoxic medium 1 h | Downregulate PTEN Antiapoptosis | [115] |
|
hP-MSCs | miR-200a-3p | FVB mice/right kidney ischemia for 50 mins | Activated Keap1-Nrf2 pathway Antioxidation | [116] |
|
Mouse BMMSCs | CCR2 | BALB/c mice/left kidney ischemia for 1 h | Absorb CCL2 Anti-inflammation | [117] |
|
Mouse ADMSCs | miR-486 | C57BL/KsJ db/db mice | Inhibit Smad1/mTOR pathway Promote autophagy Antiapoptosis | [118] |
|
GI-MSCs | miRNAs | SCID mice/left kidney ischemia for 35 mins | Promote proliferation | [119] |
|
RAPCs | miR-218, Robo-1 | C57BL/6 mice/bilateral kidney ischemia for 30 mins | Promote migration | [120] |
|
ECFCs | miR-486-5p | FVB mice/bilateral kidney ischemia | Downregulate PTEN Activate Akt pathway | [121] |
|
EPCs | miR-126-3p miR-126-5p | CD-1 outbred mice/CLP | Downregulate HMGB1 and VCAM1 | [122] |
|