The Influence of the Surface Topographical Cues of Biomaterials on Nerve Cells in Peripheral Nerve Regeneration: A Review

Table 2

Summary of the effects of sizes on cell adhesion and migration.

Feature type	Effects on cell behaviors	Reference
Prepared poly(L-lactic acid-co-e-caprolactone) (P(LLA-CL)) nanofibers	Have different regulatory effects on macrophage activation	[49]
Polylactide-glycolide copolymers were used to prepare random and longitudinally arranged electrospun fibers such as two-dimensional films and three-dimensional films	Increase in the adhesion of Schwann cells	[50]
Arranged nanofibers	Neurites extended preferentially along the long axis	[53]
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) PHBV nanofibers doped with polyethylene oxide (PEO)	Promoted adhesion and proliferation of Schwann cells	[55]
Micron-scale groove	Limiting the migration and diffusion of the cytoskeleton	[65]
Used a polystyrene colloidal template to make a surface with controlled feature sizes	When the surface feature size is reduced to less than 200 nm, cell adhesion, diffusion, viability, and activity are enhanced	[68]