Activated Human Umbilical Cord Blood Platelet-Rich Plasma Enhances the Beneficial Effects of Human Umbilical Cord Mesenchymal Stem Cells in Chemotherapy-Induced POF Rats

<div>The combined transplantation of HucMSCs and ucPRP accelerates the recovery of ovarian angiogenesis and follicular development marker expression. (a) The expression of the D15 ovarian angiogenesis marker CD34 and the follicular development markers AMH and FSHR. (b) CD34 staining was located in the ovarian stroma and corpus luteum. The MVD score assessed the changes in the expression of CD34 ovarian angiogenesis markers. Scale bar: 500 <i>μ</i>m, 100 <i>μ</i>m. (c) AMH mainly located in the ovarian granulosa cells. The <svg height="8.68572pt" id="M133" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 11.0606 8.68572" width="11.0606pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M828 650H570L564 622C646 614 650 609 634 524L604 366H253L281 524C296 608 308 615 382 622L388 650H132L126 622C211 615 214 609 198 524L121 122C106 42 102 35 23 28L17 0H276L282 28C196 35 191 40 206 122L243 324H597L559 123C544 42 537 35 452 28L446 0H710L716 28C632 35 628 43 643 122L719 524C735 610 741 615 822 622L828 650Z"></path></g></svg> score assessed the changes in the expression of the AMH ovarian development marker. Scale bar: 100 <i>μ</i>m, 25 <i>μ</i>m. (d) FSHR located in the ovarian granulosa cells. The <svg height="8.68572pt" id="M134" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 11.0606 8.68572" width="11.0606pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M828 650H570L564 622C646 614 650 609 634 524L604 366H253L281 524C296 608 308 615 382 622L388 650H132L126 622C211 615 214 609 198 524L121 122C106 42 102 35 23 28L17 0H276L282 28C196 35 191 40 206 122L243 324H597L559 123C544 42 537 35 452 28L446 0H710L716 28C632 35 628 43 643 122L719 524C735 610 741 615 822 622L828 650Z"></path></g></svg> score evaluated the expression changes in the FSHR ovarian development marker. Scale bar: 100 <i>μ</i>m, 25 <i>μ</i>m. 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Stem Cells International

fig7

Figure 7

Figure 7: Activated Human Umbilical Cord Blood Platelet-Rich Plasma Enhances the Beneficial Effects of Human Umbilical Cord Mesenchymal Stem Cells in Chemotherapy-Induced POF Rats 

Figure 7 | Activated Human Umbilical Cord Blood Platelet-Rich Plasma Enhances the Beneficial Effects of Human Umbilical Cord Mesenchymal Stem Cells in Chemotherapy-Induced POF Rats 