3D Electrospun Nanofiber-Based Scaffolds: From Preparations and Properties to Tissue Regeneration Applications

Figure 5

Electrospun PLA nanofiber/freeze-dried collagen bilayer composite scaffold for osteochondral tissue engineering. (a) The fabrication process of freeze-dried collagen bilayer scaffolds and (b) nanofiber/freeze-dried collagen bilayer composite scaffolds, and (c) their microstructures. (d) Architecture evaluation of the repaired tissues after 12 weeks of implantation by μ-CT images ((A) nontreated group, (B) freeze-dried collagen bilayer scaffold group, (C) nanofiber/freeze-dried collagen bilayer composite scaffold group, and (D) normal joints). There were abundant subchondral bones formed in the nanofiber-collagen porous scaffold group. Adapted with permission from [84]. Copyright © 2013, Acta Materialia Inc. Published by Elsevier Ltd.

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