Chromatin Regulation in Development: Current Understanding and Approaches

Figure 3

Transposable elements are marked by epigenetic signatures. (a) Dot-plot of the enrichment of transposable elements families in 8 chromatin marks and 11 bound factors in mouse TSCs. The size of the circle represents corrected enrichment P values. The colour indicates the enrichment score which was computed with a combination of the binomial test and hypergeometric test [89]. (b) Dot-plot of the enrichment of transposable elements families in open chromatin regions defined by ATAC-seq peaks in human eight-stage blastocysts, naïve ESCs, primed ESCs, blastocyst-derived TSCs, H9-derived TSCs, and AN1 iPSC-derived TSCs. The size of the circle represents corrected enrichment P values. The colour indicates the enrichment score which was computed with a combination of the binomial test and hypergeometric test [89].

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