Myogenic Differentiation of Stem Cells for Skeletal Muscle Regeneration

Figure 1

Schematic diagram of muscle regeneration. Skeletal muscle tissue regeneration is regulated by a genetic cascade involving Pax7 and MRFs, which drive every step of satellite cell activation, transient expansion of progenitor cells, and the differentiation and formation of new muscle fibers. Interestingly, satellite cell self-renewal can retain a small number of rested cells after regeneration to meet future regeneration needs.