Stem Cells International / 2021 / Article / Tab 2 / Review Article
The Effects of Mesenchymal Stem Cell on Colorectal Cancer Table 2 The general clinical application of MSCs.
Systems Disease Effect Mechanism Reference Respiratory system Bronchopulmonary dysplasia; non-small cell lung cancer; ARDS; asthma inflammation; diabetic lung fibrosis Improve lung function; reduce pulmonary fibrosis; relieve pulmonary hypertension Increase the “M2” macrophages; mitochondrial transfer; adjusting Sirt3-mediated responses; exosomal transfer of miR-144 [70 , 86 –89 ] Digestive system IBD; intestinal ischemia-reperfusion injury (IRI) Suppression of inflammatory responses; improve I/R-induced intestinal damage; improve gut barrier function IL-10; macrophage polarization; TSG-6 through hyaluronan-CD44 interactions in an Akt-dependent manner; promote Claudin-3, Claudin-2, and ZO-1 expression; NLRP3-related signaling pathways [90 –94 ] Endocrine system Type 2 diabetes mellitus (T2DM) Reduce blood glucose levels; reverse insulin resistance Inhibition of STZ-induced β -cell apoptosis; activation of autophagy via the AMPK pathway; blockade of the NLRP3 inflammasome activation [95 –97 ] Immune system Rheumatoid arthritis; systemic lupus erythematosus (SLE); allergic asthma Reduce joint destruction; improve the immune system Restore the balance between memory T cells populations; miRNA-150-5p; release TGF-β 1 to generate CD4 + CD25 + Foxp3 + T-reg cells; expand IL-10 producing lung interstitial macrophages [98 –102 ] Nervous system Stroke; neuroinflammation Improve neurological impairment and long-term neuroprotection; attenuate neuroinflammation Inhibiting STAT3-dependent autophagy; microRNA cluster miR-17-92 [103 –107 ]