Sox9-Increased miR-322-5p Facilitates BMP2-Induced Chondrogenic Differentiation by Targeting Smad7 in Mesenchymal Stem Cells

<div>The NGS and bioinformatic analysis demonstrated that silencing of Sox9 decreased the expression of miR-322-5p which was predicted to target Smad7. (a) The volcano plot showed the upregulated and downregulated miRNAs in the BMP2+shSox9 group. (b) The Venn diagram analysis revealed that only two downregulated miRNAs, including miR-322-5p, appeared in all three databases. (c) The correlation coefficient between groups was 0.9, and miR-322-5p was marked. FC: fold change.</div>

Stem Cells International

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Figure 2

Figure 2: Sox9-Increased miR-322-5p Facilitates BMP2-Induced Chondrogenic Differentiation by Targeting Smad7 in Mesenchymal Stem Cells 