Sox9-Increased miR-322-5p Facilitates BMP2-Induced Chondrogenic Differentiation by Targeting Smad7 in Mesenchymal Stem Cells

<div>The Sox9/miR-322-5p/Smad7 axis was confirmed by qPCR, WB, and dual-luciferase reporter assay. (a) Relative expression levels of miR-322-5p among groups at different time points. (b) Predicted consequential pairing of Smad7 and miR-322-5p. (c) Dual-luciferase reporter assay confirmed the targeting relationship between Smad7 and miR-322-5p. (d) qPCR revealed the silencing effect of miR-322-5p on Smad7. (e, f) Results of WB were consistent with those of qPCR. 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Stem Cells International

fig3

Figure 3

Figure 3: Sox9-Increased miR-322-5p Facilitates BMP2-Induced Chondrogenic Differentiation by Targeting Smad7 in Mesenchymal Stem Cells 