Review Article
Strategies to Improve the Efficiency of Transplantation with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke: A Review of Recent Progress
Table 2
Recent studies reporting chemical agents that can improve the efficiency of MSC transplantation in ischemic stroke models.
| Chemical agents | Possible mechanisms | Animal model | Source of MSC | Research time | References |
| VX-765 | Improving the cell survival by upregulating of autophagy via AMPK/mTOR | Rat cerebral infarction model | Umbilical cord (human) | 2020 | Sun et al. [56] | Oncostatin M | Promoting migration ability of MSCs by upregulating SDF-1 | Rat cerebral infarction model | Bone marrow (rat) | 2019 | Han et al. [66] | Tetramethylpyrazine | Promoting cell homing by CXCL12/CXCR4 signaling pathway. | Rat cerebral infarction model | Bone marrow (rat) | 2019 | Li et al. [53] | Minocycline | Upregulating NeuN and VEGF in ischemic area boundary | Rat cerebral infarction model | Bone marrow (human) | 2018 | Cho et al. [58] | Mannitol and temozolomide | Increasing the BBB permeability | Rat cerebral infarction model | Umbilical cord (human) | 2018 | Choi et al. [68] | Stroke patient serum | Promoting neurogenesis and angiogenesis | Rat cerebral infarction model | Bone marrow (human) | 2018 | Moon et al. [72] | Palmitic acid-peptide | Promoting migration ability of MSCs | Rat cerebral infarction model | Bone marrow (rat) | 2017 | Huang et al. [67] | Tetramethylpyrazine | Promoting survival of MSCs against H2O2-induced apoptosis by PI3K/AKT and ERK1/2 pathways | Cell model of cerebral ischemia | Bone marrow (rat) | 2017 | Fang et al. [52] | Valproate and lithium | Promoting cell homing and migration ability by activating CXCL12/CXCR4 and MMP9 | Rat cerebral infarction model | Not mentioned | 2011 | Tsai et al. [60] |
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