Strategies to Improve the Efficiency of Transplantation with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke: A Review of Recent Progress

Table 3

Recent studies reporting TCM and extracts that can improve the efficiency of MSC transplantation in ischemic stroke models.

Drug name	Extraction source	Possible mechanisms	Animal model	Source of MSC	Research time	References
Salvia miltiorrhiza	Salvia miltiorrhiza Bunge	Promoting the antiapoptotic ability and survival of MSCs	Rat cerebral infarction model	Bone marrow (rat)	2018	Kim et al. [80]
Angelica gigas extract	Angelica gigas	Enhancing neovascularization	Rat cerebral infarction model	Bone marrow (rat)	2018	Kim et al. [85]
Borneol	Artemisia and Dipterocarpaceae	Suppressing apoptosis and promoting neurogenesis	Mouse cerebral infarction model	Fetal mice	2017	Zhang et al. [83]
Astragaloside and baicalin		Improving the antiapoptosis and anti-inflammatory ability of MSCs by MAPK/ERK pathway	Cell inflammatory model induced by lipopolysaccharide	Bone marrow (mice)	2017	Zhu et al. [81]
Buyang Huanwu decoction	TCM prescription	Augmenting angio-miRNA in MSC-secreted exosomes	Rat cerebral infarction model	Not mentioned	2015	Yang et al. [78]
Buyang Huanwu decoction	TCM prescription	Upregulating VEGF and Ki-67	Rat cerebral infarction model	Bone marrow (rat)	2010	Zhang et al. [77]