Adipose-Derived Stem Cell-Derived Extracellular Vesicles Inhibit the Fibrosis of Fibrotic Buccal Mucosal Fibroblasts via the MicroRNA-375/FOXF1 Axis

<div>ADSC-EVs are internalized by fBMFs. fBMFs were treated with 100 <i>μ</i>g ADSC-EVs for 24 h. (a) miR-375 expression in fBMFs was detected using RT-qPCR. (b) The internalization of EVs-miR-375 by fBMFs; fBMF nuclei were labeled with DAPI (blue) and EVs-miR-375 were labeled with PKH26 (red). GW4869: treatment of ADSC conditioned medium supplemented with EV inhibitor GW4869; EVs: treatment of ADSC-EVs; EVs-miR-375/EVs-NC: treatment of EVs derived from ADSCs transfected with miR-375 mimic or NC mimic. 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Stem Cells International

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Figure 3

Figure 3: Adipose-Derived Stem Cell-Derived Extracellular Vesicles Inhibit the Fibrosis of Fibrotic Buccal Mucosal Fibroblasts via the MicroRNA-375/FOXF1 Axis 

Figure 3 | Adipose-Derived Stem Cell-Derived Extracellular Vesicles Inhibit the Fibrosis of Fibrotic Buccal Mucosal Fibroblasts via the MicroRNA-375/FOXF1 Axis 