Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells

Figure 8

Schematic diagram demonstrating the signaling pathway in the context of ectomesenchymal interaction for maintenance and proliferation of DESCs in mouse incisor cervical loop. Nfic is involved the cell proliferation and maintenance of DESCs in two different pathways. Within the dental epithelium, it mediates FGF8-NFIC-SOX2 signaling pathway. In the dental mesenchymal stem cell, Nfic induces FGF10 which controls the proliferation of dental epithelial stem cells.

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