Fludarabine/Cyclophosphamide Conditioning Regimen in Aplastic Anemia Patients Receiving Matched-Sibling Donor Transplant Is Non-inferior to ATG/Cyclophosphamide: A Single-Center Experience from Pakistan

Table 4

Multivariate analysis for factors affecting overall survival, GvHD-free survival, and relapse-free survival.

		OS			GFS			RFS
		HR	95% CI	value	HR	95% CI	value	HR	95% CI	value
Conditioning	Flu/Cy	1			1			1
	ATG/Cy	0.48	0.22-1.10	0.084	0.47	0.21-1.06	0.072	0.44	0.19-1.00	0.050
TNC		1			1			1
		1.97	0.95-4.07	0.066	1.99	0.96-4.12	0.064	1.85	0.90-3.82	0.093
CD34	≥2.6	1			1			1
	<2.6	3.18	1.46-6.94	0.003	3.11	1.43-6.75	0.004	3.09	1.41-6.75	0.005
Primary graft failure	No	1			1			1
	Yes	13.22	5.30-33.02	<0.001	11.32	4.56-28.11	<0.001	14.18	5.67-35.43	<0.001
Secondary graft failure	No	1			1			1
	Yes	6.45	2.74-15.17	<0.001	5.45	2.33-12.79	0.001	7.97	3.33-19.05	<0.001

Multivariate Cox regression analyses were applied for hazard ratios. A multiple Cox regression analysis was run to predict OS, GFS, and RFS from conditioning, TNC, CD34, primary graft failure, and secondary graft failure.