miR-100-5p Promotes Epidermal Stem Cell Proliferation through Targeting MTMR3 to Activate PIP3/AKT and ERK Signaling Pathways

Figure 5

miR-100-5p promotes epidermal stem cell proliferation through downregulating MTMR3. miR-100-5p mimics (miR-100-5p) and negative control miRNA (NC) were cotransfected human epidermal cells with MTMR3 expression plasmid (MTMR3) or control vector (Vector), respectively. The MTMR3 mRNA level was examined by RT-qPCR after 24 h (a). Cell proliferation was examined at different periods of time by MTT assay (b). Data are shown as , . , , and , comparison between cells cotransfected with miR-100-5p + Vector and cells cotransfected with NC + Vector; and , comparison between cells cotransfected with miR-100-5p + MTMR3 and cells cotransfected with miR-100-5p + Vector; and , comparison between cells cotransfected with NC + MTMR3 and cells cotransfected with NC + Vector.

(a)

(b)