Identification and Validation of a Potential Stemness-Associated Biomarker in Hepatocellular Carcinoma

Figure 2

Relationship between the mRNAsi and clinical characteristics and weighted gene coexpression network analysis (WGCNA). (a) Differences in mRNAsi between normal and tumor tissues. (b) Survival curves of high/low mRNAsi group in HCC patients. (c–m) Differences in mRNAsi and clinical characteristics: age (c), gender (d), grade (e), stage (f), fetoprotein value (g), cancer status (h), T/N/M stages (i–k), Ishak score (l), or vascular invasion (m). (n) The cluster dendrogram was based on the expression data of the top 5,000 genes with the MAD by WGCNA. (o) Heatmap of correlation between ME and mRNAsi/EGFR-mRNAsi. (p) Distribution of average gene significance and errors in the modules associated with mRNAsi. (q) Scatter plot of MEs in the blue module. (r, s) GO and KEGG enrichment analyses of genes in blue (r) and turquoise (s) module by Metascape.

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