Hypoxia Enhances HIF1α Transcription Activity by Upregulating KDM4A and Mediating H3K9me3, Thus Inducing Ferroptosis Resistance in Cervical Cancer Cells

Figure 2

Hypoxia induced upregulation of KDM4A in CC cells. SiHa and Hela cell lines were treated with hypoxia for 0.5, 1, 2, 4, and 12 h. (A) The expression of KDM4A in CC research data set GSE7803 was obtained from the Oncomine database; (B-C) The mRNA and protein levels of KDM4A in CC cells were detected by RT-qPCR and Western blot. The experiments were conducted in 3 replicates independently. The data were expressed as mean ± standard deviation. One-way ANOVA was used for comparisons among groups with Tukey’s multiple comparisons test as the post hoc test; vs. the normal group, p <0.05.

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