Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation-Related Tumorigenesis via Modulating Macrophages

Figure 6

HUC-MSCs regulate immune cell balance. (a) Transplant of HUC-MSCs downregulated activated macrophage in the colon mucosa. With the treatment with DSS, the activated macrophages in the colon mucosa were significantly increased, whereas therapy with HUC-MSCs, the percentage of activated macrophages was decreased greatly. (b) HUC-MSCs have no significant effect on the proportion of B cells in DSS-induced colitis mice. (c, d) Transplant of HUC-MSCs decreased Th1 and Th2 in DSS-induced colitis mice. (e, f) Transplant of HUC-MSCs decreased Th17 while increased Treg in DSS-induced colitis mice. (g–j) The influence of HUC-MSCs on differentiation and secretion of macrophages. Error bars: . ; ; .

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