Conjugated Linoleic Acid Treatment Attenuates Cancerous features in Hepatocellular Carcinoma Cells

Figure 1

The proliferation rate and colony formation capacity of Hep-3B and Sk-Hep-1 cells after treatment with CLA or BIM for 48 h. (a) Sk-Hep-1 and Hep-3B cells which were treated with different concentrations of CLA (30, 60, 80, and 100 μM) showed a significant reduction in proliferation rate in a dose-dependent manner as compared to the control groups (). Also the proliferation rates in both cell lines increased significantly after treatment with BIM. (b), (c), (d), (e) CLA treatment reduced the number of colonies and total area of them in both cell lines compared to the control groups. Also, the number and total area of colonies in BIM treated groups increased significantly compared to the control groups in both cell lines. Data are presented as the , (, , , and ).

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