Extracellular Vesicles Derived from Adipose Mesenchymal Stem Cells Promote Peritoneal Healing by Activating MAPK-ERK1/2 and PI3K-Akt to Alleviate Postoperative Abdominal Adhesion

<div>Impact of ADSC-EVs on peritoneal mesothelium cells and peritoneal matrix-related factors. (a) Immunohistochemical staining of E-cadherin in the injured areas peritoneum in each group of rats. RPMCs are shown by black arrow (100x in the upper plate, 200x in the below plate). (b–f) The expression of COL1, MMP-9, TIMP-1, <i>α</i>-SMA, and fibronectin was evaluated at 15 days postsurgery by immunohistochemistry assay (100x in the upper plate, 200x in the below plate). (g) Quantitative analysis of peritoneal matrix-related factors at 15 days. Bars, 50 <i>μ</i>m. 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Stem Cells International

fig5

Figure 5

Figure 5: Extracellular Vesicles Derived from Adipose Mesenchymal Stem Cells Promote Peritoneal Healing by Activating MAPK-ERK1/2 and PI3K-Akt to Alleviate Postoperative Abdominal Adhesion 

Figure 5 | Extracellular Vesicles Derived from Adipose Mesenchymal Stem Cells Promote Peritoneal Healing by Activating MAPK-ERK1/2 and PI3K-Akt to Alleviate Postoperative Abdominal Adhesion 