Mesenchymal Stromal Cells Mediate Clinically Unpromising but Favourable Immune Responses in Kidney Transplant Patients

Figure 5

Model of immune cell regulation post-MSC administration in autologous KTx patients. MSC infusion leads to increase in naïve T cells, B_REGS, and DN T cells and decrease in the memory and effector T cell population. Increase in B_REGS and DN T cell possibly inhibits T_EFF cell function. B_REGS can also act as antigen-presenting cells (APC) which form immune complexes with T_NAI cells ultimately leading to T_EFF cell apoptosis.