Gene Function Fold change References ACHE Assists in neurotransmission 170.62 0.300763 [57 ] APOE Provides neuronal protection and repair after injury 43.96 0.037188 [58 ] ASCL1 Neuronal commitment in differentiation 99.59 0.015643 [59 ] BMP4 Stimulates neuronal differentiation via ERK pathway 7.75 0.004901 [60 ] BMP8B Mediates remodelling of the neurovascular network in ADSCs 139.55 0.245330 [61 ] CHRM2 Excitation of neurons, synaptic plasticity, and feedback regulation of ACHE 87.91 0.036105 [62 ] CXCL1 Critical role in migration in the brain; allows for BBB permeabilization 45.45 0.035850 [7 ] DCX Assists in neuronal homing 87.91 0.036105 [63 ] DLL1 Regulates Notch signalling; mediates cell fate determination 36.79 0.039993 [64 ] DRD2 Synthesis and regulation of dopamine; synaptic plasticity 53.13 0.037051 [65 ] GRIN1 Regulation of synapsis 87.91 0.036105 [66 ] HEY2 Key role in brain development 138.59 0.182292 [67 ] HEYL Promotes neuronal differentiation of NPCs 87.91 0.036105 [68 ] IL3 Regulates proliferation and survival of NPCs 87.91 0.036105 [69 ] MDK Assists in proliferation and migration 51.20 0.036887 [70 ] NEUROD1 Essential for the survival and differentiation of newborn neurons 87.91 0.036105 [71 ] NEUROG1 Encourages neurite outgrowth 71.08 0.095615 [72 ] NEUROG2 Regulates differentiation of NPCs 264.66 0.353172 [73 ] NOG Required for proper CNS development 87.91 0.036105 [74 ] NR2E3 Maintains and regulates neural stem and neocortex development 58.40 0.037037 [75 ] NRCAM Responsible for neuronal cell adhesion 20.08 0.015638 [76 ] NTN1 Plays a role in axon guidance and cell homing during neuronal network development 87.91 0.036105 [77 ] TENM1 Organizes the synaptic network by matching synaptic partners: axons and target projection neuronal cells 87.91 0.036105 [78 ] OLIG2 Determines motor neuron and oligodendrocyte differentiation; sustains replication in early neuronal development; regulates proliferation of NPCs 118.99 0.005325 [79 ] PAX3 Impacts proliferation, survival, differentiation, and motility 87.91 0.036105 [80 ] PAX5 Provides neuroprotection and aids in the healing of injured neurons 21.73 0.050238 [81 ] POU3F3 Involved in CNS development 147.51 0.123322 [82 ] POU4F1 Important for differentiation, axonal elongation, and cell survival 87.91 0.036105 [83 ] S100B Aids in normal CNS formation and recovery following injury 56.68 0.037128 [84 ] SHH Promotes proliferation and differentiation 44.16 0.037775 [85 ] SOX2 Essential in self-renewal maintenance of NSCs; directs the differentiation of SCs to neuronal differentiation 180.77 0.218528 [86 ] SOX8 Aids in NPC specification and cell survival 14.37 0.020562 [87 ] SOD1 Protects the cell from ROS 0.85 0.614984 [88 ] TNR Encourage neurite outgrowth and neural cell adhesion, proliferation and migration, axonal guidance, myelination, and synaptic plasticity 87.91 0.036105 [89 ]
