E3 Ubiquitin Ligase CHIP Inhibits the Interaction between Hsp90<i>β</i> and MAST1 to Repress Radiation Resistance in Non-Small-Cell Lung Cancer Stem Cells

<div>Plot of the molecular mechanism of E3 ubiquitin ligase CHIP in radioresistance of NSCLC stem cells. E3 ubiquitin ligase CHIP promotes the ubiquitination of MAST1 by blocking the interaction of Hsp90<i>β</i> with MAST1, leading to a decrease in MAST1 protein stability, thus inhibiting NSCLC stem cell properties and promoting radiosensitivity.</div>

Stem Cells International

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Figure 6

Figure 6: E3 Ubiquitin Ligase CHIP Inhibits the Interaction between Hsp90<i>β</i> and MAST1 to Repress Radiation Resistance in Non-Small-Cell Lung Cancer Stem Cells 

Figure 6 | E3 Ubiquitin Ligase CHIP Inhibits the Interaction between Hsp90β and MAST1 to Repress Radiation Resistance in Non-Small-Cell Lung Cancer Stem Cells 