Stem Cell Therapy and Innate Lymphoid Cells

Figure 1

Differentiation of ILCs from hematopoietic stem cells (HSCs): HSCs differentiate into lymphoid-primed multipotent progenitors (LMPPs) and common myeloid progenitors (CMPs). LMPPs further differentiate into early innate lymphoid progenitors (EILP) and common lymphoid progenitors (CLPs). CLPs give rise to T and B cells whereas ELPs differentiate into common helper ILC progenitors (CHILPs) and NK cells. CHILPs further differentiate to produce PLZF-dependent ILC1s, ILC2s, and ILC3s.