Research Article
FAIM Enhances the Efficacy of Mesenchymal Stem Cell Transplantation by Inhibiting JNK-Induced c-FLIP Ubiquitination and Degradation
Figure 3
FAIM regulated the expression of c-FLIP in MSCs under OGD conditions. (a–b) Immunoblots and densitometric quantitation of cleaved caspase-8 and cleaved caspase-9 protein levels in MSCsVec and MSCsFAIM under OGD conditions. (c–d) Immunoblots and densitometric quantitation of c-FLIP protein levels in MSCsVec and MSCsFAIM under OGD conditions. (e–f) c-FLIP protein levels after siRNA-mediated knockdown of FAIM or scrambled siRNA administration followed by OGD stimulation for 12 h. The results of densitometric quantification are shown on the right. The data are shown as the . indicates not significant; denotes , .
| (a) |
| (b) |
| (c) |
| (d) |
| (e) |
| (f) |