Research Article
FAIM Enhances the Efficacy of Mesenchymal Stem Cell Transplantation by Inhibiting JNK-Induced c-FLIP Ubiquitination and Degradation
Figure 6
FAIM reduces c-FLIP degradation by blocking JNK activation. (a–b) Immunoblots and densitometric quantitation of phosphorylated JNK and total JNK protein expression in MSCsVec and MSCsFAIM under OGD conditions. (c–d) Western blotting and densitometric quantitation of phosphorylated JNK and total JNK protein expression in MSCssi-scr and MSCssi-FAIM under OGD conditions. (e–f) Phosphorylated JNK, total JNK, and c-FLIP protein expression after siRNA-mediated knockdown of FAIM or scrambled siRNA administration followed by treatment with SP600125 (a JNK inhibitor, 10 μM) or DMSO under OGD conditions. The data are shown as the . indicates not significant; denotes ; .
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