Human Mesenchymal Stem Cells Derived from the Placenta and Chorion Suppress the Proliferation while Enhancing the Migration of Human Breast Cancer Cells

<div>Effect of soluble factors derived from CH-hMSCs and PL-hMSCs on the proliferation of human breast cancer MCF-7 cells. (a) Graphs show the growth kinetics of MCF-7 cells cultured in 10%, 25%, 50%, and 75% conditioned media derived from CH-hMSCs (CH-CM) and PL-hMSCs (PL-CM) determined by the MTT assay. Data are presented as <svg height="8.55521pt" id="M29" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 6.36303 8.55521" width="6.36303pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M137 343C167 482 260 545 321 574C357 591 397 603 429 609L423 641C382 634 335 622 295 608C189 570 37 457 37 238C37 84 125 -12 242 -12C362 -12 447 89 447 209C447 311 374 393 267 393C247 393 226 386 204 376L137 343ZM227 337C318 337 361 256 361 173C361 105 336 22 258 22C176 22 126 120 126 240C126 266 127 291 132 310C155 323 189 337 227 337Z"></path></g></svg> of four experiments. MCF-7 cultured in DMEM medium +10% FBS served as controls. CH-CMs were prepared from 3 CH-hMSCs (CH9, CH15, and CH16) and PL-CMs were prepared from 3 PL-hMSCs (PL11, PL14, and PL17). (b) Graphs show the growth kinetic of MCF-7 cells cultured in 10%, 25%, 50%, and 75% CH-CM (average from CH9, CH15, to CH16) and PL-CM (average from PL11, PL14, to PL17). Data are presented as <svg height="9.10327pt" id="M30" style="vertical-align:-0.3499298pt" version="1.1" viewbox="-0.0498162 -8.75334 67.6442 9.10327" width="67.6442pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M797 0V26C739 32 732 36 732 103V296C732 394 682 449 605 449C576 449 550 437 529 423C504 407 475 389 446 366C425 418 382 449 334 449C303 449 279 437 253 421C222 403 201 385 180 371V452C135 432 85 419 41 411V388C99 379 102 374 102 310V103C102 38 93 32 27 26V0H238V26C189 32 180 38 180 103V338C210 363 250 390 289 390C351 390 377 348 377 275V103C377 37 368 32 306 26V0H520V26C465 32 456 38 456 101V296C456 314 455 326 453 338C491 369 529 390 565 390C628 390 653 345 653 274V107C653 36 642 32 583 26V0H797Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.595,0)"><path d="M380 106C343 72 306 56 265 56C195 56 116 112 115 248C235 252 361 262 377 265C396 269 400 277 400 297C400 374 333 449 250 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Stem Cells International

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Figure 3

Figure 3: Human Mesenchymal Stem Cells Derived from the Placenta and Chorion Suppress the Proliferation while Enhancing the Migration of Human Breast Cancer Cells 

Figure 3 | Human Mesenchymal Stem Cells Derived from the Placenta and Chorion Suppress the Proliferation while Enhancing the Migration of Human Breast Cancer Cells 