Human Mesenchymal Stem Cells Derived from the Placenta and Chorion Suppress the Proliferation while Enhancing the Migration of Human Breast Cancer Cells

Figure 6

The effect of soluble factors derived from CH-hMSCs and PL-hMSCs on the invasion of human breast cancer MDA-MB231 cells. (a) Representative micrographs of the invasive MDA-MB231 cells after coculture with CH-hMSCs and PL-hMSCs as determined by transwell invasion assay. CH-hMSCs were derived from three donors (CH9, CH15, and CH16), and PL-hMSCs were derived from three donors (PL11, PL14, and PL17). MDA-MB231 cells induced by DMEM medium +30% FBS served as controls. (b) Graphs show the number of invasive MDA-MB231 cells after being cocultured with CH-hMSCs and PL-hMSCs as determined by transwell invasion assay. Data are presented as of three experiments. CH-hMSCs were derived from three donors (CH9, CH15, and CH16), and PL-hMSCs were derived from three donors (PL11, PL14, and PL17). MDA-MB231 cells induced by DMEM medium +30% FBS served as controls. (c) Graphs show the number of invasive MDA-MB231 cells after being induced by cocultured with CH-hMSCs (average from CH9, CH15, and CH16) and PL-hMSCs (average from PL11, PL14, and PL17). Data are presented as of three hMSCs. MDA-MB231 cells cultured in DMEM medium +30% FBS served as a control.

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