Enhanced Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood and Using Their Mesoderm Differentiation Ability to Regenerate Infarcted Myocardium

Figure 6

Production of iPSCs using CiMS cells and its application in cardiovascular cell differentiation. CiMS cells separated from the endocardium of the heart can be easily isolated from the blood and have high transduction efficiency; therefore, reprogramming is efficient. These CiMS cells are specialized for differentiation into cardiovascular cells even when they become iPSCs because of the epigenetic memory of the endocardium. Therefore, the generation of CiMS-iPSCs shows great advantages in cardiovascular disease-related modeling and is an appropriate cell line for stem cell therapy in regenerative medicine.