[Retracted] Adipose-Derived Mesenchymal Stem Cell-Derived Extracellular Vesicles Rescue Tendon Injury in Rat via the miR-19 a/IGFBP3 Axis

<div>EV-derived miR-19a inhibited IGFBP3 expression through targeting its 3<svg height="7.86364pt" id="M42" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -7.81382 4.53621 7.86364" width="4.53621pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M295 534L291 558C277 573 202 603 180 597L75 72L120 51L295 534Z"></path></g></svg>UTR. (a) Putative binding sites of miR-19a and IGFBP3 mRNA 3<svg height="7.86364pt" id="M43" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -7.81382 4.53621 7.86364" width="4.53621pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M295 534L291 558C277 573 202 603 180 597L75 72L120 51L295 534Z"></path></g></svg>UTR were predicted by DIANA-LncBase V2 and Targetscan. (b) Luciferase reporter analysis was performed to detect the bindings between miR-19a and IGFBP3 in tendon cells. (c) The effect of miR-19a intervention on the expression of IGFBP3 in tendon cells was evaluated using qRT-PCR. 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Stem Cells International

fig5

Figure 5

Figure 5: [Retracted] Adipose-Derived Mesenchymal Stem Cell-Derived Extracellular Vesicles Rescue Tendon Injury in Rat via the miR-19 a/IGFBP3 Axis 