Cyclin-Dependent Kinase 1 Inhibition Potentiates the Proliferation of Tonsil-Derived Mesenchymal Stem Cells by Delaying Cellular Senescence

Figure 3

Transcriptomic profiles of young and old TMSCs. Whole-genome sequence data from young and old TMSCs are presented. (a) A cell cycle-related partial heatmap of hierarchical clustering analysis results indicates differentially expressing genes (rows) between the young and old TMSCs. Blue and orange circles indicate up- and downregulated genes, respectively, in old TMSCs compared with young TMSCs. For all comparisons, changes in gene expression are depicted as a heatmap. (b) 3D MDS plots for microarray gene expression data compared to young and old TMSCs were presented. (c) 3D dendrogram depicts the results of hierarchical clustering analysis of the interclass correlation between young and old TMSCs, confirming the classification of an interclass between the two groups. (d) The molecular function distribution of GO terms for DEGs between young and old TMSCs was annotated according to the ontology categories: molecular function (MF). The - and -axes indicate the number of DEGs and GO term gene classification, respectively (). (e) All KEGG pathways were first classified into 10 categories. (f) These categories were the top 20 terms of the KEGG pathway according to the level of significance.

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