Force-Induced Nitric Oxide Promotes Osteogenic Activity during Orthodontic Tooth Movement in Mice

<div>Force-induced NO regulated the OTM process. (a–d) The distance between the upper 1<sup>st</sup> molar and 2<sup>nd</sup> molar after 7 d force application was measured by a stereomicroscope (a) and micro-CT (b, d). Inhibition of NOS by L-NMMA injection decreases the subsequent OTM; upregulated NO level by L-arginine injections promotes OTM, (c) HE staining of the periodontal ligament of the distal root of the 1st molar, which is the tension side. 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Stem Cells International

fig2

Figure 2

Figure 2: Force-Induced Nitric Oxide Promotes Osteogenic Activity during Orthodontic Tooth Movement in Mice 