Single-Cell Transcriptome Analysis Defines Expression of Kabuki Syndrome-Associated KMT2D Targets and Interacting Partners

<div>The interaction network of KMT2D and KDM6A and scRNA-seq clustering analysis of the mouse incisor dental pulp. (a) STRING interaction network analysis revealed that both KMT2D and KDM6A associate with other components of the SET1/COMPASS complex, including KMT2C, ASH2L, WDR5, RBBP5, KDM4B, p300, NCOA6, SMARCA4, PAXIP1, and MEN1. In addition, this analysis revealed that KMT2D and KDM6A physically interact with EZH2 and SUZ12, key components of the PRC2. (b) The mouse incisor dental pulp is composed of 16 distinct cell types that represent MSCs at different stages of osteogenic and odontogenic differentiation as well as pericytes, ameloblasts, smooth muscle cells, islet cells, Schwann cells, vascular endothelial, and blood cells.</div>

Stem Cells International

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Figure 1: Single-Cell Transcriptome Analysis Defines Expression of Kabuki Syndrome-Associated KMT2D Targets and Interacting Partners 