Human Umbilical Cord Mesenchymal Stem Cells Attenuate Severe Burn-Induced Multiple Organ Injury via Potentiating IGF-1 and BCL-2/BAX Pathway

Figure 5

The hUCMSC administrations significantly increased protective cytokine IGF levels and BCL-2/BAX ratios. (a1–c1) IGF-1 levels of the heart, kidney, and liver in the burn+hUCMSC groups were significantly higher than those in the burn groups, and they in the burn group were higher than those in the sham group. BCL-2/BAX ratios of the heart, kidney, and liver in the burn groups were markedly lower than those in the sham groups, while they in the burn+hUCMSC groups were significantly higher than those in the burn groups. (a2–c2) The results of the quantitative analysis were presented in the corresponding histograms.

(a)

(b)

(c)