Knockdown of Adra2a Increases Secretion of Growth Factors and Wound Healing Ability in Diabetic Adipose-Derived Stem Cells

Figure 6

Effects of Adra2a knocked-down T2D ASCs on wound healing in T2D mice. (a) Macroscopic pictures of representative wounds of T2D mice treated with PBS, C57BL/6 ASCs, T2D ASCs, and Adra2a knocked-down T2D ASCs (namely, T2D+PBS; T2D+C57BL/6 ASC; T2D+T2D ASC; T2D+knocked-down T2D ASC groups, respectively, same as below) on day 1, 4, 7, and 10 after wounding. (b) Graphical summary of changes in wound area expressed relative to the initial size of the wound at day 1. Data are . (c) H&E staining of wound sections of T2D mice treated with PBS, C57BL/6 ASCs, T2D ASCs, and Adra2a knocked-down T2D ASCs 14 days postwounding. (d) Statistics of the number of hair follicles around the wound in the skin of T2D mice. (e) The expression of VEGF, TGF-β, TNF-α, and IL-1in the tissue of the wound area treated with PBS, C57BL/6 ASCs, T2D ASCs, and Adra2a knocked-down T2D ASCs on the 14th day.

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