Knockdown of Adra2a Increases Secretion of Growth Factors and Wound Healing Ability in Diabetic Adipose-Derived Stem Cells

Figure 7

Regulation of growth factor exocytosis by Adra2a. Activation of these receptors by epinephrine (E), norepinephrine (NE), and clonidine in ASCs results in receptor-Gi coupling that inhibits adenyl cyclase (AC). This inhibition, in turn, results in decreased conversion of ATP to cAMP and reduced protein kinase A (PKA) activity; this may increase the activation of some transcription factor- (TF-) mediated mRNA expression of growth factors and then decline the exocytosis of the growth factors in ASCs.