Immortalized Mesenchymal Stem Cells: A Safe Cell Source for Cellular or Cell Membrane-Based Treatment of Glioma

<div>Safety of immortalized mesenchymal stem cells in vivo. (a) IVIS luminescent imaging of BALB/c nude mice with intracranial injection of immortalized umbilical cord mesenchymal stem cells (1 × 10<sup>6</sup>). Line graph showing cell growth in the brain, U87 cells were used as a positive reference, and normal glial cells (HA1800) were used as a negative reference. (b) Im-hUCMSC were injected subcutaneously into the proximal right lower extremity of nude mice to evaluate tumorigenic; the picture was taken on the 14th day after injection. (c) HE staining shows that there was no abnormal tissue growth inside the brain where mesenchymal stem cells were injected. Red arrow indicates the direction of needle entry. Magnification, ×50. 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Stem Cells International

fig5

Figure 5

Figure 5: Immortalized Mesenchymal Stem Cells: A Safe Cell Source for Cellular or Cell Membrane-Based Treatment of Glioma 