Serial Gene Expression Profiling of Neural Stem Cells Shows Transcriptome Switch by Long-Term Physioxia from Metabolic Adaption to Cell Signaling Profile

Table 2

Affected pathways from upregulated genes in midbrain and cortex NSCs cultivated for 2 days in physioxia.

	Midbrain NSCs				Cortical NSCs
	Number of genes	Fold enrichment	P value		Number of genes	Fold enrichment	P value
PANTHER pathways Mus musculus (reference)				PANTHER pathways Mus musculus (reference)
Glycolysis	2	>100	8.10E-03	—
Reactome pathways Mus musculus (reference)				Reactome pathways Mus musculus (reference)
Pyruvate metabolism	3	>100	3.41E-04	Glycolysis	4	43.11	4.54E-03
				(i) Glucose metabolism	4	32.34	1.35E-02
				(ii) metabolism of carbohydrates	6	14.59	5.45E-03
				Collagen formation	4	29.40	1.94E-02