Research Article

Serial Gene Expression Profiling of Neural Stem Cells Shows Transcriptome Switch by Long-Term Physioxia from Metabolic Adaption to Cell Signaling Profile

Table 4

Affected pathways from downregulated genes in midbrain and cortex NSCs cultivated for 13 days in physioxia.

Midbrain NSCsCortical NSCs
Number of genesFold enrichmentP valueNumber of genesFold enrichmentP value

PANTHER pathways Mus musculus (reference)PANTHER pathways Mus musculus (reference)
 Notch signaling pathway418.701.35E-02Notch signaling pathway362.822.78E-03
 Wnt signaling pathway84.993.79E-02
Reactome pathways Mus musculus (reference)Reactome pathways Mus musculus (reference)
 —Transmission across chemical synapses520.556.78E-03