Implantation of Hypoxia-Induced Mesenchymal Stem Cell Advances Therapeutic Angiogenesis

Figure 6

Expression of angiogenic cytokines in cultured mesenchymal stem cells (MSCs) and hypoxia-induced MSCs (hi-MSCs) prior to implantation. hi-MSCs showed significantly higher expression levels of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor A (VEGF-A) than those in MSCs. The expression level of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) was slightly lower in the hi-MSC group than in the MSC group.