Bone Marrow Culture-Derived Conditioned Medium Recovers Endothelial Function of Vascular Grafts following In Vitro Ischemia/Reperfusion Injury in Diabetic Rats

Figure 1

Effect of ischemia/reperfusion (IR) injury on contraction and relaxation in the aorta of nondiabetic control and diabetic rats. Contractile responses for (a) phenylephrine [expressed as the percentage of the maximum contraction induced by potassium chloride (KCl)] and (b) high potassium K⁺-induced depolarization (control, rings from 8 rats; control-IR, 31 rings form 8 rats; DM, 32 rings from 8 rats; DM-IR, 40 rats from 10 rats) and (c) acetylcholine-induced endothelium-dependent vasorelaxation (control, rings from 8 rats; control-IR, 31 rings form 8 rats; DM, 31 rings from 8 rats; DM-IR, 44 rats from 11 rats) and (d) sodium nitroprusside- (SNP-) induced endothelium-independent vasorelaxation (control, rings from 8 rats; control-IR, 31 rings form 8 rats; DM, 32 rings from 8 rats; DM-IR, 44 rats from 11 rats) of isolated thoracic aortic rings obtained from nondiabetic and diabetic rats. DM indicates diabetes mellitus. Data are represented as the . versus control, ^# versus control-IR, and ^$ versus DM.

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