YTHDC1 Promotes Stemness Maintenance and Malignant Progression in Head and Neck Squamous Cell Carcinoma

Figure 1

SCC9-sphere exhibits inflated CSC-like properties. (a) The comparison of sphere formation ability between SCC9-sphere and SCC9 cell line. Scale bar, 100 μm. (b) Bar graph showed SCC9-sphere enhanced the sphere formation ability compare with the SCC9 cell line. (c) SOX2 and BMI1 protein levels in two groups. (d) Volcano plot of differentially expressed genes from RNA sequencing results. (e, f) GSEA comparing the SCC9-sphere group with the SCC9 cell line group in TNFA and EMT signaling pathway. Nominal values, false discovery rate (FDR), and normalized enrichment score (NES) were shown.

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