YTHDC1 Promotes Stemness Maintenance and Malignant Progression in Head and Neck Squamous Cell Carcinoma

Figure 5

Validation of the role of YTHDC1 in regulating stemness maintenance at the single cell level. (a) The UMAP plot of scRNA-seq cell data labeled by cell type. (b) The UMAP plot of the YTHDC1 expression in all the clusters. (c) The UMAP plot of cancer cells from HNSCC tissues shows the YTHDC1 expression pattern. (d) The Pearson correlation between YTHDC1 and SOX2 mRNA expression according to the single cell RNA data. (e) The Pearson correlation between YTHDC1 and BMI1 mRNA expression according to the single cell RNA data. (f) Volcano plot shows differentially expressed genes between YTHDC1 high and YTHDC1 low cells. (g) GO analysis of the upregulated genes in the YTHDC1 high expression cell population. (h) KEGG analysis of the upregulated genes in the YTHDC1 high expression cell population. (i) Violin plot depicts the expression of stem cell-related markers of YTHDC1 high and YTHDC1 low cells.

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