Mesenchymal Stem Cells Ameliorate Hyperglycemia in Type I Diabetic Developing Male Rats

Figure 5

(a, b) Photomicrographs of sections of the pancreas of a control developing rat illustrate closely packed lobules of normal pancreatic acini () and endocrine islets (arrow). The acini are formed of pyramidal cells with basal nuclei and apical acidophilic cytoplasm. (c, d) Photomicrographs of sections of the pancreas of a diabetic developing rat show severe reduction and shrinkage of islets of Langerhans (arrow) with degeneration and necrosis of the acini components (arrowheads) and extravasations of blood from the damaged blood capillaries forming hemorrhagic appearance (). (e, f) Photomicrographs of sections of the pancreas of a diabetic developing rat treated with mesenchymal stem cells during early phase (diabetic+MSCs1 group) show normal pancreatic acini (P) and some acinar cells with cytoplasmic degeneration. Note the increase in density (arrow) and size of islet in this group. (g, h) Photomicrographs of sections of the pancreas of a diabetic developing rats, treated with mesenchymal stem cells during late phase (diabetic+MSCs2 group), show no significant recovery. The focal acinar damage represented by cytoplasmic vacuolation (V) and the nuclei (N) exhibited karyolysis of some acinar cells with shrinkage of islets of Langerhans (arrow).

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