Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhance Alveolar Type II Cell Proliferation and Attenuate Lung Inflammation in a Rat Model of Bronchopulmonary Dysplasia

Figure 6

Location of the transtracheally delivered MVs according to the lung tissue cell types. (a) Representative immunofluorescence images of donor MVs and host lung cells staining at 48 hours after MV administration. The MVs were prestained with DiO dye (green). The nuclei were labeled with DAPI (blue); the AT1, AT2, vascular endothelial cells, total macrophages, vascular smooth muscle cells, and vascular pericytes were stained with AQP1, SP-C, CD31, Iba-1, α-SMA, and NG2 (red), respectively. (b) The rate of donor MV incorporation into each type of host lung cells (, ANOVA, NS: not significant, and ).

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