|
| Cell sources | Year | Team | Journal | Results | Reference |
|
| BMSCs | 2008 | Wuertz et al. | Spine | IVD-like acidity (pH 6.8) inhibited BMSC viability, proliferation, and expression of aggrecan and collagen-I. | [104] |
| 2009 | Wuertz et al. | Biochem Biophys Res Commun | Increased acidity inhibited BMSC viability, proliferation, and expression of aggrecan and collagen-I. | [124] |
| 2016 | Naqvi and Buckley | Spine | Acidity with pH below 6.8 inhibited BMSC viability, proliferation, and accumulation of sGAG and collagen. | [127] |
| 2019 | Cai et al. | Biosci Rep | Degenerated IVD-like acidity inhibited BMSC viability and proliferation. | [132] |
| 2021 | Gansau et al. | Eur Cell Mater | Low pH (pH 6.8 and pH 6.5) inhibited AD-MSC viability and accumulation of sGAG and collagen compared with standard pH (pH 7.4). | [133] |
|
| AD-MSCs | 2012 | Laing et al. | J Transl Med | IVD-like acidity (pH 6.8) inhibited AD-MSC viability, proliferation, and expression of aggrecan and collagen-I. | [105] |
| 2012 | Li et al. | Exp Biol Med | Acidic pH inhibited AD-MSC viability, proliferation, and expression of aggrecan, collagen-I and collagen-II. | [125] |
| 2014 | Han et al. | Cells Tissues Organs | Acidic pH inhibited AD-MSC and NP-MSC viability, proliferation, and expression of aggrecan, collagen-I, and collagen-II, and NP-MSCs exhibited higher tolerance to acidity than AD-MSCs. | [126] |
|
| NP-MSCs | 2017 | Liu et al. | Stem Cells Dev. | Acidic pH inhibited NP-MSC viability, proliferation, and ECM synthesis. | [40] |
| 2021 | Ding et al. | Aging | Acidic pH (pH 6.6) inhibited NP-MSC proliferation and induced their senescence. | [134] |
| 2022 | Wang et al. | Front Bioeng Biotechnol | Acidic conditions (pH 6.2) inhibited NP-MSC viability, proliferation, and ECM synthesis. | [135] |
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