|
| Cell sources | Year | Team | Journal | Results | Reference |
|
| Inflammatory cytokines | BMSCs | 2007 | Ponte et al. | Stem Cells | TNF-α (1 ng/mL) promoted BMSC migration. | [181] |
| 2009 | Felka et al. | Osteoarthritis Cartilage | IL-1β (2 ng/mL) inhibited the chondrogenic differentiation of BMSCs, while hypoxia (2% O2) reduced the inhibitory effect of IL-1β on the chondrogenic differentiation of BMSCs. | [77] |
| 2009 | Huang et al. | Cell Death Differ | IL-17 (50 ng/mL) promoted BMSC proliferation and migration. | [190] |
| 2011 | Mojsilović et al. | Cell Tissue Res | IL-17 (5-50 ng/mL) and bFGF (1 ng/mL) promoted the proliferation of BMSCs by activating p38 and ERK-mediated MAPK signaling pathway. | [191] |
| 2011 | Gantenbein-Ritter et al. | Eur Spine J | TGF-β1 (10 ng/mL) and GDF-5 (100 ng/mL) promoted the differentiation of BMSCs into NP-like cells. | [194] |
| 2011 | Stoyanov et al. | Eur Cell Mater | Hypoxia (2% O2) and GDF5 (100 ng/mL) promoted the differentiation of BMSCs to a NP-like phenotype. | [80] |
| 2017 | Wang et al. | Cell Death Dis | TNF-α promoted (30 ng/mL) BMSC migration. | [182] |
| 2018 | Teixeira et al. | Spine | IL-1β (10 ng/mL) promoted BMSC migration but had no effect on cell viability. | [180] |
| 2018 | Ma et al. | Ann Transplant | IL-17 (50 ng/mL) increased the homing and immunosuppressive abilities of BMSCs. | [192] |
| 2019 | Kasprzycka et al. | Stem Cell Res Ther | IL-4 (50 ng/mL) and IL-6 (50 ng/mL) inhibit BMSC proliferation but promote their migration. | [189] |
| 2021 | Xie et al. | Nat Commun | High concentration of TNF-α (100 ng/mL) promoted the directional migration of BMSCs. | [183] |
| AD-MSCs | 2014 | Clarke et al. | Arthritis Res Ther | Compared with TGF-β (10 ng/mL) or GDF-5 (100 ng/mL), GDF-6 (100 ng/mL) was more suitable for promoting the differentiation of MSCs to NP-like phenotype, and it was more pronounced in AD-MSCs than in BMSCs. | [196] |
| 2016 | Colombier et al. | Stem Cells | TGF-β1 (10 ng/mL) combined with GDF-5 (100 ng/mL) promoted the chondrogenic differentiation of AD-MSCs. | [197] |
| 2016 | Mohammadpour et al. | Immunopharmacology and Immunotoxicology | IFN-γ (10 ng/mL) alone or in combination with TNF-α (10 ng/mL) promoted the proliferation of AD-MSCs, while TNF-α (10 ng/mL) alone had no effect on the proliferation of AD-MSCs. | [185] |
| 2018 | Brandt et al. | Int J Mol Sci. | High concentrations of proinflammatory cytokines (IL-1β: 10 ng/mL and/or TNF-α: 50 ng/mL) promoted the proliferation and osteogenic differentiation of AD-MSCs but inhibited cell viability and chondrogenic differentiation. | [184] |
| 2020 | Li et al. | Biochem Biophys Res Commun. | TGF-β3 (100 ng/mL) promoted the chondrogenic differentiation of AD-MSCs. | [198] |
| 2020 | Archacka et al. | Cells | IL-4 (10 ng/mL) enhanced the migration ability of AD-MSCs. | [199] |
| 2020 | Zimowska et al. | Int J Mol Sci | IL-4 (10 ng/mL) promoted AD-MSC proliferation and migration. | [200] |
| NP-MSCs | 2015 | Tao et al. | Growth Factors | TGF-β3 (10 ng/mL) combined with IGF-1 (10 ng/mL) promoted NP-MSC viability and differentiation towards NP-like phenotype. | [195] |
| 2019 | Cheng et al. | J Cell Biochem | High concentrations of TNF-α (50-200 ng/mL) induced apoptosis of NP-MSCs, whereas a relatively low concentrations of TNF-α (0.1-10 ng/mL) promoted NP-MSC proliferation and migration but inhibited their differentiation into NP-like cells. | [186] |
| UC-MSCs | 2018 | Yang et al. | Mol Cell Biochem | IL-1β (20 ng/mL) and TNF-α (20 ng/mL) inhibited the proliferation of UC-MSCs but promoted their chondrogenic differentiation, and IL-6 (20 ng/mL) inhibited the chondrogenic differentiation of UC-MSCs. | [187] |
| PMSCs | 2007 | Li et al. | Cells Tissues Organs | Proinflammatory cytokines (IL-1, IL-6, and IL-8) promoted the proliferation of PMSCs in a dose-dependent manner, while anti-inflammatory cytokine (IL-4) inhibited the proliferation of PMSCs in a dose-dependent manner. | [201] |
| 2018 | Yi et al. | Cellular Immunology | IFN-γ (20 ng/mL) inhibited the proliferation and migration of PMSCs. | [203] |
| 2020 | Zhang et al. | Cell Immunol | IL-1β (20 ng/mL or 30 ng/mL) promoted the migration of PMSCs but inhibited cell proliferation. | [202] |
| AF-MSCs | 2011 | Park et al. | Biomaterials | TGF-β3 (100 ng/mL) promoted the proliferation and chondrogenic differentiation of AF-MSCs. | [205] |
| AMSCs | 2019 | Borem et al. | J Orthop Res | Compared with AD-MSCS, the same inflammation conditions promoted chondrogenic differentiation of AMSC. | [207] |
| PB-MSCs | 2018 | Calle et al. | Stem Cell Res Ther | IL-1β promoted the migration of AD-MSCs and PB-MSCs. | [206] |
|
| MMP | BMSCs | 2006 | Neth et al. | Stem Cells | MT1-MMP promoted BMSC proliferation and migration. | [210] |
| 2007 | Ries et al. | Blood | MMP-2, MT1-MMP, and TIMP-2 promoted BMSC migration, while TIMP-1 inhibited their migration. | [211] |
| 2010 | Lu et al. | Blood | MT1-MMP dominated BMSC migration and differentiation into NP-like cells. | [212] |
| 2013 | Sun et al. | Cell Signal | MT1-MMP promoted BMSC proliferation. | [213] |
| 2016 | Gao et al. | Mol Reprod Dev | Silencing MMP-2 reduced BMSC proliferation and migration. | [214] |
| AD-MSCs | 2019 | He et al. | Am J Physiol Heart Circ Physiol | MMP-9 promoted AD-MSC proliferation and migration. | [215] |
| 2020 | Rong et al. | Dermatol Ther | Overexpression of MMP-3 reduced the expression level of collagen-I in AD-MSCs. | [216] |
| NP-MSCs | 2019 | Zhang et al. | Cell Signal | Downregulation of MMP-3 promoted the chondrogenic differentiation of NP-MSCs. | [217] |
| UC-MSCs | 2014 | Marquez-Curtis et al. | Stem Cells Int | Increased expression of MMP-2 promoted UC-MSC migration. | [218] |
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