Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy

Table 1

Cord blood elements that may contribute to neuroregeneration.

Fraction	Potential role in brain regeneration	Reference
Hematopoietic stem cells	Release of vascular endothelial growth factor and glial-derived neurotrophic; factor which stimulate neurogenesis and angiogenesis	[65]
Mesenchymal stem cells	Reduce oxidative stress, neuroinflammation, and cell death; transfer mitochondria to injured cells	[68–71]
Regulatory T cells	Suppress autoimmunity	[60–62]
Monocytes	Mediate the neuroprotective effects via expressing several secreted; proteins and immunoregulation	[57–59]
Progenitors	Decrease neuroinflammation, cell apoptosis, and free radical production	[55, 63]